Research

Publications

2024

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2023

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2022

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2021

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2020

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2019

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2018

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2017

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2016

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2015

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2014

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2013

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2012

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

2011

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

Pre IU Publications

40
2023

de Gombert, A.; Darù, A.; Ahmed, T.; Haibach, M.; Li-Matsuura, R.; Yang, C.; Henry, R.; Cook, S. P.; Shekhar, S.; Blackmond, D. “Mechanistic Insight into Cu-Catalyzed C-N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions,” ACS Cat., 2023, 13(5), 2904–2915 (DOI: 10.1021/acscatal.0c02965).

39
2023

Pinter, E. N.; Sheldon, Z. S.; Modak, A.; Cook, S. P. “Fluorosulfonamide-Directed Heteroarylation of Aliphatic C(sp3)–H Bonds,” J. Org. Chem., 2023, xx, xx-xx. [DOI: 10.1021/acs.joc.2c02461].

38
2023

Lee, H.; He, T.; Cook, S. P. “Iron-Catalyzed, Directed Benzylic Borylation,” Org. Lett., 2023, 25(1), 1–4. [DOI: 10.1021/acs.orglett.2c02864].

37
2022

Liu, Z. and Cook, S. P. “Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds,” Org. Lett., 202224(18), 3313–3318. [DOI: 10.1021/acs.orglett.2c00447].

36
2021

He, J.; Nguyen, T.; Guo, S.; Cook, S. P. “Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems,” Org. Lett., 2021, 23(3), 702-705. [DOI: 10.1021/acs.orglett.0c03891].

35
2020

Liu, Z. and Cook, S. P. “Interrupting the Barton-McCombie: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates,” Org. Lett., 2020, 23(3), 808–813. [DOI: 10.1021/acs.orglett.0c04039].

34
2020

Modak, A.; Nett, A. J.; Swift, E. C.; Haibach, M. C.; Chan, V. S.; Franczyk, T. S. Shekhar, S.; Cook, S. P. “Cu-Catalyzed C-N Coupling with Sterically Hindered Partners,” ACS Cat., 2020, 141, 18405–18410 (DOI: 10.1021/acscatal.0c02965).

Highlights:

  • Synfacts 2020, 16, 1434 (DOI: 10.1055/s-0040-1719552).

33
2020

Pinter, E. N.; Bingham, J. E., AbuSalim, D. I., and Cook, S. P. “N-Directed Fluorination of Unactivated Csp3–H Bonds,” Chem. Sci., 202011, 1102–1106 (10.1039/c9sc04055b).

32
2019

Modak, A.; Pinter, E. N.; Cook, S. P. “Copper-Catalyzed, N-Directed Csp3–H Trifluromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3),” J. Am. Chem. Soc., 2019141, 18405–18410 (10.1021/jacs.9b10316).

31
2019

Groendyke, B.; Modak, A.; Cook, S. P. " Fenton-Inspired C–H Functionalization: Peroxide-Directed C–H Thioetherification," J. Org. Chem., 201984, 13073–13091 (10.1021/jacs.9b101979).

30
2019

Marcyk, P. T. and Cook, S. P. “Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination,”Org. Lett., 2019, 21, 6741–6744[10.1002/acs.orglett.9b02353]

29
2019

Guo, S.; AbuSalim, D. I.; Cook, S. P. “1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group,” Angew. Chem. Int. Ed., 2019, 58, 11704–11708[10.1002/anie.201905247]

28
2019

Sahota, N.; AbuSalim, D. I.; Wang, M. L.; Brown, C. J.; Zhang, Z.; El-Baba, T. J.; Cook, S. P.; Clemmer, D. E. “A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS,” Chem. Sci., 2019, 10, 4822–4827[10.1039/C9SC00704K].

27
2019

Marcyk, P. T. and Cook, S. P. “Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes,” Org. Lett., 2019, 21, 1547–1550[10.1021/acs.orglett.9b00427]

26
2019

Marcyk, P. T.; Jefferies, L. R.; AbuSalim, D. I.; Pink, M.; Baik, M.-H.; Cook, S. P. “Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides,”Angew. Chem. Int. Ed., 2019, 58, 1727–1731[10.1002/anie.201812894]

25
2018

Guo, S.; AbuSalim, D. I.; Cook, S. P. “Aqueous Benzylic Trifluoromethylation for Late-Stage Functionalization,” J. Am. Chem. Soc., 2018140, 12378–12382[10.1021/jacs.8b08547One of the "Most Read" papers in JACS for October!

24
2018

Rosas Vargas, D.; Cook, S. P. “Palladium Nanoparticles: Chemoselective Control of the Reductive Heck with Aryl Triflates and 2,3-Dihydrofuran,” Tetrahedron201874, 3314–3317[10.1016/j.tet.2018.04.052Invited Paper in honor of Professor Seth Herzon receiving the Tetrahedron Young Investigator Award.

23
2017

Le Sueur, A. L.; Ramos, S.; Ellefsen, J. D.; Cook, S. P.; Thielges, M. C. “Evaluation of p-(13C,15N-Cyano)phenylalanine as an Extended Time Scale 2D IR Probe of Proteins,” Anal. Chem. 201789, 5254–5260. [10.1021/acs.analchem.6b04650]

22
2016

Groendyke, B.; AbuSalim, D. I.; Cook, S. P. “Iron-Catalyzed, Fluoroamide-Directed C–H Fluorination,” J. Am. Chem. Soc., 2016138, 12771–12774[10.1021/jacs.6b08171] Highlighted in: C&E News 2016, 94, 40, October 10th. [link]

21
2016

Atack, T. C. and Cook, S. P. “Manganese-Catalyzed Borylation of Unactivated Chlorides,” J. Am. Chem. Soc., 2016138, 6139–6142[10.1021/jacs.6b03157] Highlighted in: ChemInform 201647. [10.1002/chin.201646196]

20
2015

Jefferies, L. R.; Weber, S. R.; Cook, S. P. “Iron-Catalyzed C–N Bond Formation via the Beckmann Rearrangement,” Synlett, 201526, 331–334[10.1055/s-0034-1379540Invited Paper for the "Catalysis with Sustainable Metals" Special Issue.

19
2014

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards," Org. Lett., 2014 16, 5080–5083 . [10.1021/ol024344]

18
2014

Fruchey, E. R.; Monks, B. M.; Cook, S. P. "A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides," J. Am. Chem. Soc., 2014,136, 13130–13133[10.1021/ja506823u]

17
2014

Monks, B. M.; Fruchey, E. R.; Cook, S. P. "Iron-Catalyzed C(sp2)–H Alkylation of Carboxamides with Primary Electrophiles,"Angew. Chem. Int. Ed., 2014, 53, 11065–11069[anie.201406594Selected as "Hot Paper" by Angew. Chem.

16
2014

Atack, T. C.; Lecker, R. M.; Cook, S. P. "Iron-Catalyzed Borylation of Alkyl Electrophiles," J. Am. Chem. Soc., 2014136, 9521–9523[10.1021/ja505199u] Highlighted in: Org. Proc. Res. Dev201418, 1047-1082. [10.1021/op500257q] Synfacts 201410, 1070. [10.1055/s-0034-1379113] ChemInform 201546, A. [10.1002/chin.201506218] Org. Chem. Highlights 2015, May 25. [link]

15
2014

Jefferies, L. R.; Cook, S. P. “Alcohols as Electrophiles: Iron-Catalyzed Ritter Reactions and Benzyl Alcohol Additions to Alkynes,” Tetrahedron201470, 4204–4207[10.1016/j.tet.2014.03.072Invited Paper in honor of Professor Sarah Reisman receiving the Tetrahedron Young Investigator Award.

14
2014

Jefferies, L. R.; Cook, S. P. “Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols,” Org. Lett.201416, 2026–2029[10.1021/ol500606d] Highlighted in: Synfacts 201410, 747. [10.1055/s-0033-1339147] Org. Chem. Highlights 2014, October 13. [link]

13
2014

Cook, S. P. “Artemisinin: A Case Study in the Evolution of Synthetic Strategy,” Synlett201425, 751–759[10.1055/s-0033-1340627Invited Synpacts review.

12
2013

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed, Intramolecular Iodine-Transfer Reactions in the Presence of β-Hydrogens," Angew. Chem. Int. Ed., 201352, 14214–14218[anie.201308534]

11
2013

Fruchey, E. R.; Monks, B. M.; Patterson, A. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins," Org. Lett.201315, 4362–4365. [10.1021/ol4018694]

10
2013

Cook, S. P. "The quest for affordable artemisinin," Future Med. Chem.20135, 233–236. [10.4155/fmc.13.1Invited editorial.

9
2013

DeLuca, R. J.; Edwards, J. L.; Steffens, L. D.; Michel, B. W.; Qiao, X.; Zhu, C.; Cook, S. P.; Sigman, M. S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP," J. Org. Chem.201378, 1682–1686. [10.1021/jo302638v]

8
2013

Agrawal, T.; Cook, S. P. "Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates," Org. Lett., 201315, 96–99. [10.1021/ol303130j] Highlighted in: Org. Proc. Res. Dev. 201317, 320-329. [10.1021/op400031g] Synfacts 2013, 9, 422. [10.1055/s-0032-1318378]

7
2012

Monks, B. M.; Cook, S. P. "Palladium-Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides," J. Am. Chem. Soc., 2012134, 15297–15300. [10.1021/ja3077611f]

6
2012

Zhu, C.; Cook, S. P. "A Concise Synthesis of (+)-Artemisinin," J. Am. Chem. Soc., 2012134, 13577–13579. [10.1021/ja3061479] Highlighted in: One of 2012's "Most Read" papers in JACS. C&E News 201290, 28. [link] JACS Spotlights 2012134, 15163–15164. [10.1021/ja3084187] Nature Chemical Biology 2012, 8, 808. [10.1038/nchembio.1073] "Synfact of the Month" Synfacts 2012, 11, 1163. [10.1055/s-0032-1317408] Nature Chemistry 20124, 772. [10.1038/nchem.1473] "Synthesis: A Constructive Debate" Nature 2012492, 188. [10.1038/492188a] Org. Chem. Highlights 2013, April 15. [link]

5
2012

Gao, P.; Cook, S. P. "A Reductive-Heck Approach to the Hydroazulene Ring System: A Formal Synthesis of the Englerins," Org. Lett., 201214, 3340–3343. [10.1021/ol3013167]

4
2012

Jarugumilli, G. K.; Zhu, C.; Cook, S. P. "Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions," Eur. J. Org. Chem., 2012, 1712–1715. [10.1002/ejoc.201200067]

3
2011

Jarugumilli, G. K.; Cook, S. P. "A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates," Org. Lett., 201113, 1904–1907. [10.1021/ol200059u]

2
2011

This is a publication

1
Pre-IU Publications

Polara, A.; Cook, S. P.; Danishefsky, S. J. “Multiple Chirality Transfers in the Enantioselective Synthesis of 11-O-debenzoyltashironin. Chiroptical Analysis of the Key Cascade,” Tetrahedron Lett. 200849, 5906–5908.
 
Vincent, F.; Cook, S. P.; Johnson, E. O.; Emmert, D.; Shah, K. “Engineering Unnatural Nucleotide Specificity to Probe G Protein Signaling,” Chem. Biol. 200714, 1007–1018.
 
Cook, S. P.; Polara, A.; Danishefsky, S. J. “The Total Synthesis of 11-O-Debenzoyltashironin,” J. Am. Chem. Soc. 2006128, 16440–16441.
 
Cook, S. P.; Danishefsky, S. J. “An Interesting Issue of Diels-Alder Selectivity Discovered En Route to 11-O-Debenzoyltashironin,” Org. Lett20068, 5693–5695.
 
Cook, S. P.; Gaul, C.; Danishefsky, S. J. “En Route to the Total Synthesis of Tashironin:  On the Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions,” Tetrahedron Lett200546, 843–847.
 
Miura, M.; Morris, G. M.; Micca, P. L.; Nawrocky, M. M.; Makar, M. M.; Cook, S. P.; Slatkin, D. N. “Synthesis of Copper Octabromotetracarboranylphenylporphyrin for Boron Neutron Capture Therapy and its Toxicity and Biodistribution in Tumour-Bearing Mice,” Br. J. Radiol. 200477, 573–580.
 
Cook, S. P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I; “Direct Calcium Binding Results in the Activation of Brain Serine Racemase,” J. Biol. Chem2002, 277, 27782–27792.

Members