Inspiration for research in the Cook Group derives from the complex challenges presented by organic synthesis. Our group develops new reactions that enable the efficient synthesis of biologically relevant small molecules. These reaction manifolds provide novel modes of bond formation in an environmentally sustainable fashion. By examining known mechanistic data, we identify gaps in understanding that can be exploited to create entirely new reaction pathways. Further mechanistic refinement in our laboratory leads to a clearer understanding of these catalytic processes, which permits the design of new reactions in a rational and systematic fashion.


Mar 23, 2023

Truong Nguyen          2021 – Pfizer, Groton, CT Zhiyun Liu                    2021 – Assistant Professor, Northwest A&F University, Shaanxi, China Atanu Modak             2020 – Snapdragon Chemistry, Waltham MA Hanbin Lee                 2020 – Samsung Shuo Guo                    2019 – Postdoc…

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Catalysis for the Future

The search for novel reactivity will lead to new breakthroughs in catalysis. Catalysis research in the Cook Group is somewhat “metal agnostic” to enable the targeting of the most difficult of bond disconnections. Our work in palladium catalysis, for example, is focused on developing underutilized pathways for palladium to create new reactions and more sustainable carbon-carbon bond-forming transformations. Our work toward “green” catalysis has led to the development of transformations employing Mn, Fe, and Cu. Remarkably, these catalysts enable reactions that simply would not proceed using precious metals. The goal is to discover complementary reactivity to other well explored systems such as Ni, Pd, and Pt.


See our recent collaborative mechanistic work on our novel Ullmann coupling!

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N-directed aliphatic fluorination

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Bis-trifluoromethylation to access E-HFBs, a new class of olefin

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A new collaboration with the Thielges group

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Microdroplet-accelerated Biginelli

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Interested in joining the Cook Lab?

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